|T000008, K10 Tracer

Compound Image

T000008

K10 Tracer

Properties

Store at:

-80 °C

Absorption:

450 nm

Emission:

590 nm
References

Contributing Lab:

Promega Corp., Madison

Vendor:

Promega
Experimental

Assay window 13.5

\(Z'\) 0.82

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

66 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

7 nM

raw data

Comment: NLuc-AAK1

Reference: source

Assay window 2.23

\(Z'\) 0.83

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

858 nM

raw data

Tracer displacement

i

Compound used for displacement:

Bosutinib

\(\mathrm{EC}_{50}\):

18563 µM

raw data

Comment: NLuc-ABL1(Q252H)

Reference: source

Assay window 2.23

\(Z'\) 0.93

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

836 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

3 nM

raw data

Comment: NLuc-ABL2

Reference: source

Assay window 6.1

\(Z'\) 0.78

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

9 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

25 nM

raw data

Comment: AURKA-NLuc

Reference: source

Assay window 9.4

\(Z'\) 0.6

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

9 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

7 nM

raw data

Comment: AURKB-NLuc

Reference: source

Assay window 9.1

\(Z'\) 0.71

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

22 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

7 nM

raw data

Comment: AURKC-NLuc

Reference: source

Assay window 3.0

\(Z'\) 0.91

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

157 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

13 nM

raw data

Comment: AXL-NLuc

Reference: source

Assay window 7.15

\(Z'\) 0.78

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

174 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

38 nM

raw data

Comment: NLuc-BMP2K

Reference: source

Assay window 3.59

\(Z'\) 0.91

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

609 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

6 nM

raw data

Comment: BMX-NLuc

Reference: source

Assay window 3.3

\(Z'\) 0.85

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

62 nM

raw data

Tracer displacement

i

Compound used for displacement:

PD-173955

\(\mathrm{EC}_{50}\):

38 nM

raw data

Comment: BRAF(V600E)-NLuc

Reference: source

Assay window 5.16

\(Z'\) 0.92

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

518 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

2 nM

raw data

Comment: NLuc-BRSK1

Reference: source

Assay window 3.42

\(Z'\) 0.88

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

791 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

5 nM

raw data

Comment: NLuc-BRSK2

Reference: source

Assay window 4.82

\(Z'\) 0.94

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

1053 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

15 nM

raw data

Comment: BTK-NLuc

Assay window 2.7

\(Z'\) 0.82

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

720 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

5 nM

raw data

Comment: BTK(C481S)-NLuc

Reference: source

Assay window 4.9

\(Z'\) 0.86

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

308 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

6 nM

raw data

Comment: BTK(E41K)-NLuc

Assay window 3.88

\(Z'\) 0.56

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

167 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

5 nM

raw data

Comment: BTK(P190K)-NLuc

Assay window 3.91

\(Z'\) 0.7

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

645 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

10 nM

raw data

Comment: NLuc-CAMK2A

Reference: source

Assay window 5.54

\(Z'\) 0.86

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

452 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

24 nM

raw data

Comment: NLuc-CAMK2D

Reference: source

Assay window 2.52

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

638 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

6 nM

raw data

Comment: CAMK2G-NLuc

Reference: source

Assay window 2.97

\(Z'\) 0.74

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

551 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

94 nM

raw data

Comment: CDK1-NLuc + CycB1

Reference: source

Assay window 3.03

\(Z'\) 0.91

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

485 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

91 nM

raw data

Comment: CDK1-NLuc + CycE1

Reference: source

Assay window 3.23

\(Z'\) 0.63

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

663 nM

raw data

Tracer displacement

i

Compound used for displacement:

SNS-032

\(\mathrm{EC}_{50}\):

71 nM

raw data

Comment: CDK10-NLuc + CycL2

Reference: source

Assay window 2.94

\(Z'\) 0.9

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

520 nM

raw data

Tracer displacement

i

Compound used for displacement:

SNS-032

\(\mathrm{EC}_{50}\):

941 nM

raw data

Comment: CDK14-NLuc + CycY

Reference: source

Assay window 2.87

\(Z'\) 0.92

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

172 nM

raw data

Tracer displacement

i

Compound used for displacement:

AT7519

\(\mathrm{EC}_{50}\):

195 nM

raw data

Comment: NLuc-CDK15 + CycY

Reference: source

Assay window 4.22

\(Z'\) 0.9

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

366 nM

raw data

Tracer displacement

i

Compound used for displacement:

AT7519

\(\mathrm{EC}_{50}\):

119 nM

raw data

Comment: CDK16-NLuc + CycY

Reference: source

Assay window 5.66

\(Z'\) 0.88

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

457 nM

raw data

Tracer displacement

i

Compound used for displacement:

AT7519

\(\mathrm{EC}_{50}\):

260 nM

raw data

Comment: CDK17-NLuc + CycY

Reference: source

Assay window 4.83

\(Z'\) 0.79

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

537 nM

raw data

Tracer displacement

i

Compound used for displacement:

AT7519

\(\mathrm{EC}_{50}\):

858 nM

raw data

Comment: CDK18-NLuc + CycY

Reference: source

Assay window 6.96

\(Z'\) 0.6

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

364 nM

raw data

Tracer displacement

i

Compound used for displacement:

AT7519

\(\mathrm{EC}_{50}\):

1 µM

raw data

Comment: CDK2-NLuc + CycA1

Reference: source

Assay window 7.07

\(Z'\) 0.87

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

647 nM

raw data

Tracer displacement

i

Compound used for displacement:

AT7519

\(\mathrm{EC}_{50}\):

516 nM

raw data

Comment: CDK2-NLuc + CycE1

Reference: source

Assay window 6.55

\(Z'\) 0.95

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

422 nM

raw data

Tracer displacement

i

Compound used for displacement:

AT7519

\(\mathrm{EC}_{50}\):

2 µM

raw data

Comment: CDK2-NLuc

Reference: source

Assay window 7.57

\(Z'\) 0.74

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

488 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

195 nM

raw data

Comment: NLuc-CDK20 + CycH

Reference: source

Assay window 4.7

\(Z'\) 0.93

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

503 nM

raw data

Tracer displacement

i

Compound used for displacement:

AT7519

\(\mathrm{EC}_{50}\):

573 nM

raw data

Comment: CDK3-NLuc + CycE1

Reference: source

Assay window 3.0

\(Z'\) 0.79

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

422 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

94 nM

raw data

Comment: NLuc-CDK4 + CycD1

Reference: source

Assay window 4.33

\(Z'\) 0.9

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

312 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

136 nM

raw data

Comment: NLuc-CDK4 + CycD3

Reference: source

Assay window 9.28

\(Z'\) 0.82

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

591 nM

raw data

Tracer displacement

i

Compound used for displacement:

APY-69

\(\mathrm{EC}_{50}\):

32 nM

raw data

Comment: CDK5-NLuc + CDK5R1

Reference: source

Assay window 9.07

\(Z'\) 0.86

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

635 nM

raw data

Tracer displacement

i

Compound used for displacement:

APY-69

\(\mathrm{EC}_{50}\):

15 nM

raw data

Comment: CDK5-NLuc + CDK5R2

Reference: source

Assay window 2.37

\(Z'\) 0.85

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

540 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

21 nM

raw data

Comment: NLuc-CDK6 + CycD1

Reference: source

Assay window 3.05

\(Z'\) 0.84

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

793 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dinaciclib

\(\mathrm{EC}_{50}\):

212 nM

raw data

Comment: NLuc-CDK7 + pGEM

Reference: source

Assay window 3.26

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

248 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

47 nM

raw data

Comment: NLuc-CDK9 + CycK

Reference: source

Assay window 2.6

\(Z'\) 0.74

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

612 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

132 nM

raw data

Comment: NLuc-CDK9 + CycT1

Reference: source

Assay window 2.23

\(Z'\) 0.83

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

290 nM

raw data

Tracer displacement

i

Compound used for displacement:

APY-69

\(\mathrm{EC}_{50}\):

8 nM

raw data

Comment: NLuc-CDKL1

Reference: source

Assay window 7.46

\(Z'\) 0.73

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

363 nM

raw data

Tracer displacement

i

Compound used for displacement:

APY-69

\(\mathrm{EC}_{50}\):

3 nM

raw data

Comment: NLuc-CDKL2

Reference: source

Assay window 2.28

\(Z'\) 0.82

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

327 nM

raw data

Tracer displacement

i

Compound used for displacement:

APY-69

\(\mathrm{EC}_{50}\):

2 nM

raw data

Comment: NLuc-CDKL3

Reference: source

Assay window 3.69

\(Z'\) 0.63

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

355 nM

raw data

Tracer displacement

i

Compound used for displacement:

APY-69

\(\mathrm{EC}_{50}\):

1 nM

raw data

Comment: NLuc-CDKL5

Reference: source

Assay window 2.01

\(Z'\) 0.7

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

817 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

12 nM

raw data

Comment: NLuc-CHEK1

Reference: source

Assay window 2.02

\(Z'\) 0.86

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

127 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

906 nM

raw data

Comment: CHEK2-NLuc

Reference: source

Assay window 2.63

\(Z'\) 0.75

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

823 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

236 nM

raw data

Comment: NLuc-CILK1

Reference: source

Assay window 5.37

\(Z'\) 0.92

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

282 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

7 nM

raw data

Comment: NLuc-CLK1

Reference: source

Assay window 4.54

\(Z'\) 0.95

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

380 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

73 nM

raw data

Comment: CLK2-NLuc

Reference: source

Assay window 3.18

\(Z'\) 0.93

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

134 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

39 nM

raw data

Comment: CLK4-NLuc

Reference: source

Assay window 3.04

\(Z'\) 0.86

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

533 nM

raw data

Tracer displacement

i

Compound used for displacement:

TAE-684

\(\mathrm{EC}_{50}\):

396 nM

raw data

Comment: NLuc-COQ8B

Reference: source

Assay window 2.4

\(Z'\) 0.6

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

948 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

2 µM

raw data

Comment: NLuc-CSNK1A1L

Reference: source

Assay window 2.25

\(Z'\) 0.82

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

794 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

1 µM

raw data

Comment: NLuc-CSNK1D

Reference: source

Assay window 2.37

\(Z'\) 0.78

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

806 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

315 nM

raw data

Comment: NLuc-CSNK1G2

Reference: source

Assay window 2.77

\(Z'\) 0.87

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

358 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

122 nM

raw data

Comment: CSNK2A1-NLuc

Reference: source

Assay window 6.2

\(Z'\) 0.9

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

188 nM

raw data

Tracer displacement

i

Compound used for displacement:

CTx-0294885

\(\mathrm{EC}_{50}\):

606 nM

raw data

Comment: CSNK2A2-NLuc

Reference: source

Assay window 2.61

\(Z'\) 0.95

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

456 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

111 nM

raw data

Comment: NLuc-DAPK2

Reference: source

Assay window 1.6

\(Z'\) 0.6

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

6460 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

50 nM

raw data

Assay window 2.39

\(Z'\) 0.84

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

623 nM

raw data

Tracer displacement

i

Compound used for displacement:

TAE-684

\(\mathrm{EC}_{50}\):

2 µM

raw data

Comment: DCLK3-NLuc

Reference: source

Assay window 9.6

\(Z'\) 0.88

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

26 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

8 nM

raw data

Assay window 2.15

\(Z'\) 0.93

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

858 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

10 nM

raw data

Comment: NLuc-DMPK

Reference: source

Assay window 2.26

\(Z'\) 0.82

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

487 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

75 nM

raw data

Comment: NLuc-DYRK1A

Reference: source

Assay window 2.73

\(Z'\) 0.97

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

309 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

35 nM

raw data

Comment: NLuc-DYRK1B

Reference: source

Assay window 2.1

\(Z'\) 0.83

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

451 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

351 nM

raw data

Comment: DYRK2-NLuc

Reference: source

Assay window 3.34

\(Z'\) 0.96

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

994 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

2 µM

raw data

Comment: NLuc-EIF2AK4 (Domain 2, 590-1001)

Reference: source

Assay window 2.45

\(Z'\) 0.93

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

664 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

129 nM

raw data

Comment: EPHA1-NLuc

Reference: source

Assay window 2.32

\(Z'\) 0.74

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

584 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

198 nM

raw data

Comment: EPHA4-NLuc

Reference: source

Assay window 2.82

\(Z'\) 0.81

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

373 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

13 nM

raw data

Comment: EPHA6-NLuc

Reference: source

Assay window 4.5

\(Z'\) 0.97

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

377 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

108 nM

raw data

Comment: EPHA7-NLuc

Reference: source

Assay window 2.19

\(Z'\) 0.87

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

757 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

5 nM

raw data

Comment: EPHB1-NLuc

Reference: source

Assay window 2.27

\(Z'\) 0.94

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

775 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

94 nM

raw data

Comment: EPHB4-NLuc

Reference: source

Assay window 2.61

\(Z'\) 0.92

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

241 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

2 µM

raw data

Comment: ERN1-NLuc

Reference: source

Assay window 3.18

\(Z'\) 0.84

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

406 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

25 nM

raw data

Comment: ERN2-NLuc

Reference: source

Assay window 2.67

\(Z'\) 0.88

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

446 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

170 nM

raw data

Comment: FER-NLuc

Reference: source

Assay window 2.36

\(Z'\) 0.7

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

476 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

620 nM

raw data

Comment: FES-NLuc

Reference: source

Assay window 3.9

\(Z'\) 0.94

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

232 nM

raw data

Tracer displacement

i

Compound used for displacement:

TAE-684

\(\mathrm{EC}_{50}\):

387 nM

raw data

Comment: FGFR1-NLuc

Reference: source

Assay window 2.9

\(Z'\) 0.77

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

138 nM

raw data

Tracer displacement

i

Compound used for displacement:

TAE-684

\(\mathrm{EC}_{50}\):

311 nM

raw data

Comment: FGFR2-NLuc

Assay window 2.54

\(Z'\) 0.88

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

205 nM

raw data

Tracer displacement

i

Compound used for displacement:

TAE-684

\(\mathrm{EC}_{50}\):

2 µM

raw data

Comment: FGFR3-NLuc

Reference: source

Assay window 2.58

\(Z'\) 0.91

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

158 nM

raw data

Tracer displacement

i

Compound used for displacement:

TAE-684

\(\mathrm{EC}_{50}\):

2 µM

raw data

Comment: FGFR3(G697C)-NLuc

Reference: source

Assay window 2.46

\(Z'\) 0.65

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

755 nM

raw data

Tracer displacement

i

Compound used for displacement:

CTx-0294885

\(\mathrm{EC}_{50}\):

69 nM

raw data

Comment: FGFR4-NLuc

Reference: source

Assay window 2.02

\(Z'\) 0.91

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

95 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

43 nM

raw data

Comment: FLT1-NLuc

Reference: source

Assay window 2.57

\(Z'\) 0.76

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

130 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

17 nM

raw data

Comment: FLT3-NLuc

Assay window 2.83

\(Z'\) 0.76

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

15 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

18 nM

raw data

Comment: FLT3(D835H)-NLuc

Reference: source

Assay window 3.16

\(Z'\) 0.61

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

11 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

54 nM

raw data

Comment: FLT3(D835V)-NLuc

Reference: source

Assay window 3.19

\(Z'\) 0.63

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

13 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

33 nM

raw data

Comment: FLT3(D835H)-NLuc

Reference: source

Assay window 2.46

\(Z'\) 0.58

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

26 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

2 nM

raw data

Comment: FLT3(K663Q)-NLuc

Reference: source

Assay window 3.2

\(Z'\) 0.83

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

33 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

7 nM

raw data

Comment: FLT3(N841I)-NLuc

Reference: source

Assay window 2.7

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

34 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

2 nM

raw data

Comment: FLT3(R834Q)-NLuc

Reference: source

Assay window 2.45

\(Z'\) 0.93

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

262 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

535 nM

raw data

Comment: FYN-NLuc

Reference: source

Assay window 3.32

\(Z'\) 0.73

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

130 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

2 µM

raw data

Comment: FYN(Y531F)-NLuc

Reference: source

Assay window 10.56

\(Z'\) 0.64

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

43 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

528 nM

raw data

Comment: NLuc-GAK

Reference: source

Assay window 2.45

\(Z'\) 0.86

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

746 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

74 nM

raw data

Comment: NLuc-HIPK2

Reference: source

Assay window 2.37

\(Z'\) 0.55

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

1044 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

190 nM

raw data

Comment: NLuc-HIPK3

Reference: source

Assay window 11.23

\(Z'\) 0.88

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

366 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

5 µM

raw data

Comment: NLuc-HIPK4

Reference: source

Assay window 2.0

\(Z'\) 0.63

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

179 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

6 µM

raw data

Comment: IGF1R-NLuc

Reference: source

Assay window 3.77

\(Z'\) 0.75

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

525 nM

raw data

Tracer displacement

i

Compound used for displacement:

CEP-701

\(\mathrm{EC}_{50}\):

239 nM

raw data

Comment: NLuc-IKBKE

Reference: source

Assay window 2.61

\(Z'\) 0.73

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

189 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

3 µM

raw data

Comment: INSR-NLuc

Reference: source

Assay window 3.65

\(Z'\) 0.82

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

20 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

8 nM

raw data

Comment: NLuc-IRAK3

Reference: source

Assay window 6.04

\(Z'\) 0.91

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

154 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

17 nM

raw data

Comment: IRAK4-NLuc

Reference: source

Assay window 3.42

\(Z'\) 0.88

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

67 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

7 µM

raw data

Comment: NLuc-ITK

Reference: source

Assay window 3.75

\(Z'\) 0.77

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

186 nM

raw data

Tracer displacement

i

Compound used for displacement:

Ruxolitinib

\(\mathrm{EC}_{50}\):

6 nM

raw data

Comment: JAK2(V617F)-NLuc

Reference: source

Assay window 2.49

\(Z'\) 0.85

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

566 nM

raw data

Tracer displacement

i

Compound used for displacement:

Ruxolitinib

\(\mathrm{EC}_{50}\):

23 nM

raw data

Comment: JAK2 (JH1 domain, 840–1132)

Reference: source

Assay window 2.99

\(Z'\) 0.9

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

419 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

35 nM

raw data

Comment: JAK3-NLuc

Reference: source

Assay window 2.06

\(Z'\) 0.82

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

324 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

89 nM

raw data

Comment: KIT(A829P)-NLuc

Reference: source

Assay window 2.15

\(Z'\) 0.8

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

272 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

67 nM

raw data

Comment: KIT(D816H)-NLuc

Reference: source

Assay window 3.35

\(Z'\) 0.91

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

263 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

1 µM

raw data

Comment: KIT(D816V)-NLuc

Reference: source

Assay window 2.27

\(Z'\) 0.71

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

228 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

44 nM

raw data

Comment: KIT(V559D)-NLuc

Reference: source

Assay window 3.93

\(Z'\) 0.78

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

99 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

754 nM

raw data

Comment: LATS1-NLuc

Reference: source

Assay window 3.52

\(Z'\) 0.77

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

16 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

642 nM

raw data

Comment: LATS2-NLuc

Reference: source

Assay window 2.48

\(Z'\) 0.88

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

364 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

224 nM

raw data

Comment: LCK-NLuc

Reference: source

Assay window 4.22

\(Z'\) 0.76

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

992 nM

raw data

Tracer displacement

i

Compound used for displacement:

HG-9-91-01

\(\mathrm{EC}_{50}\):

18 nM

raw data

Comment: LIMK1-NLuc

Reference: source

Assay window 5.22

\(Z'\) 0.94

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

468 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

179 nM

raw data

Comment: LIMK2-NLuc

Reference: source

Assay window 2.7

\(Z'\) 0.84

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

16 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

4 nM

raw data

Comment: LRRK2-NLuc

Assay window 2.09

\(Z'\) 0.73

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

16 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

3 nM

raw data

Comment: LRRK2(G2019S)-NLuc

Reference: source

Assay window 3.93

\(Z'\) 0.95

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

136 nM

raw data

Tracer displacement

i

Compound used for displacement:

TAE-684

\(\mathrm{EC}_{50}\):

6 nM

raw data

Comment: LTK-NLuc

Reference: source

Assay window 4.05

\(Z'\) 0.93

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

159 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

456 nM

raw data

Comment: NLuc-MAP3K10

Reference: source

Assay window 4.28

\(Z'\) 0.91

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

175 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

20 nM

raw data

Comment: NLuc-MAP3K11

Reference: source

Assay window 2.72

\(Z'\) 0.94

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

350 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

1 µM

raw data

Comment: NLuc-MAP3K12

Reference: source

Assay window 2.12

\(Z'\) 0.68

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

77 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

305 nM

raw data

Comment: MAP3K19-NLuc

Reference: source

Assay window 2.25

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

248 nM

raw data

Tracer displacement

i

Compound used for displacement:

CEP-701

\(\mathrm{EC}_{50}\):

2 µM

raw data

Comment: MAP3K2-NLuc

Reference: source

Assay window 2.6

\(Z'\) 0.59

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

434 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

114 nM

raw data

Comment: NLuc-MAP3K20

Reference: source

Assay window 2.3

\(Z'\) 0.8

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

524 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

1 µM

raw data

Comment: NLuc-MAP3K21

Reference: source

Assay window 2.28

\(Z'\) 0.82

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

318 nM

raw data

Tracer displacement

i

Compound used for displacement:

Bosutinib

\(\mathrm{EC}_{50}\):

2 µM

raw data

Comment: MAP3K3-NLuc

Reference: source

Assay window 3.93

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

767 nM

raw data

Tracer displacement

i

Compound used for displacement:

CTx-0294885

\(\mathrm{EC}_{50}\):

84 nM

raw data

Comment: MAP3K4-NLuc

Reference: source

Assay window 2.63

\(Z'\) 0.79

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

146 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

10 nM

raw data

Comment: NLuc-MAP3K9

Reference: source

Assay window 4.15

\(Z'\) 0.9

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

244 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

186 nM

raw data

Comment: NLuc-MAP4K1

Reference: source

Assay window 3.13

\(Z'\) 0.88

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

116 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

8 nM

raw data

Comment: NLuc-MAP4K2

Reference: source

Assay window 4.41

\(Z'\) 0.8

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

554 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

113 nM

raw data

Comment: NLuc-MAP4K3

Reference: source

Assay window 2.38

\(Z'\) 0.66

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

2007 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

118 nM

raw data

Comment: MAP4K5-NLuc

Reference: source

Assay window 2.45

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

193 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

235 nM

raw data

Comment: MAPK10-NLuc

Reference: source

Assay window 4.04

\(Z'\) 0.72

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

806 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

1 µM

raw data

Comment: NLuc-MAPK11

Reference: source

Assay window 3.19

\(Z'\) 0.81

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

559 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

136 nM

raw data

Comment: MAPK14-NLuc

Reference: source

Assay window 5.98

\(Z'\) 0.95

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

263 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

399 nM

raw data

Comment: MAPK14(T106M)-NLuc

Reference: source

Assay window 7.64

\(Z'\) 0.74

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

16 nM

raw data

Tracer displacement

i

Compound used for displacement:

TMLH98

\(\mathrm{EC}_{50}\):

118 nM

raw data

Comment: NLuc-MAPK15

Assay window 17.93

\(Z'\) 0.75

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

60 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

14 nM

raw data

Comment: NLuc-MAPK4

Reference: source

Assay window 11.68

\(Z'\) 0.83

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

16 nM

raw data

Tracer displacement

i

Compound used for displacement:

CTx-0294885

\(\mathrm{EC}_{50}\):

48 nM

raw data

Comment: NLuc-MAPK6

Reference: source

Assay window 3.75

\(Z'\) 0.7

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

174 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

111 nM

raw data

Comment: NLuc-MAPK8

Reference: source

Assay window 5.02

\(Z'\) 0.78

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

217 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

514 nM

raw data

Comment: NLuc-MAPK9

Reference: source

Assay window 3.54

\(Z'\) 0.94

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

480 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

1 nM

raw data

Comment: NLuc-MARK2

Reference: source

Assay window 2.44

\(Z'\) 0.82

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

1081 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

3 nM

raw data

Comment: NLuc-MARK3

Reference: source

Assay window 3.15

\(Z'\) 0.87

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

295 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

2 nM

raw data

Comment: NLuc-MARK4

Assay window 2.13

\(Z'\) 0.93

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

444 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

388 nM

raw data

Comment: NLuc-MAST3

Reference: source

Assay window 2.25

\(Z'\) 0.81

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

412 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

542 nM

raw data

Comment: NLuc-MAST4

Reference: source

Assay window 2.62

\(Z'\) 0.91

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

1911 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

373 nM

raw data

Comment: NLuc-MELK

Reference: source

Assay window 3.18

\(Z'\) 0.85

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

584 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

357 nM

raw data

Comment: NLuc-MELK(T460M)

Reference: source

Assay window 2.14

\(Z'\) 0.93

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

102 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

7 nM

raw data

Comment: MERTK(A708S)

Reference: source

Assay window 3.23

\(Z'\) 0.88

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

543 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

6 nM

raw data

Comment: MET-NLuc

Reference: source

Assay window 4.4

\(Z'\) 0.91

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

393 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

35 nM

raw data

Comment: MET(D1228H)-NLuc

Reference: source

Assay window 5.25

\(Z'\) 0.84

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

355 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

26 nM

raw data

Comment: MET(D1228N)-NLuc

Reference: source

Assay window 6.0

\(Z'\) 0.95

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

341 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

156 nM

raw data

Comment: MET(F1200I)-NLuc

Reference: source

Assay window 5.45

\(Z'\) 0.93

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

243 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

9 nM

raw data

Comment: MET(M1250T)-NLuc

Reference: source

Assay window 4.03

\(Z'\) 0.8

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

353 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

14 nM

raw data

Comment: MET(P991S)-NLuc

Reference: source

Assay window 3.53

\(Z'\) 0.84

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

484 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

11 nM

raw data

Comment: MET(T1173I)-NLuc

Reference: source

Assay window 3.86

\(Z'\) 0.84

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

394 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

4 nM

raw data

Comment: MET(T992I)-NLuc

Reference: source

Assay window 5.87

\(Z'\) 0.88

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

364 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

1 nM

raw data

Comment: MET(V1092I)-NLuc

Reference: source

Assay window 5.5

\(Z'\) 0.78

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

364 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

9 nM

raw data

Comment: MET(Y1230A)-NLuc

Reference: source

Assay window 4.5

\(Z'\) 0.72

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

460 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

4 nM

raw data

Comment: MET(Y1230C)-NLuc

Reference: source

Assay window 4.55

\(Z'\) 0.9

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

312 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

8 nM

raw data

Comment: MET(Y1230D)-NLuc

Reference: source

Assay window 5.9

\(Z'\) 0.85

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

306 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

6 nM

raw data

Comment: MET(Y1230H)-NLuc

Reference: source

Assay window 2.68

\(Z'\) 0.86

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

858 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

4 nM

raw data

Comment: MET(Y1235D)-NLuc

Reference: source

Assay window 2.53

\(Z'\) 0.86

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

672 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

73 nM

raw data

Comment: NLuc-MKNK2

Reference: source

Assay window 4.37

\(Z'\) 0.59

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

449 nM

raw data

Tracer displacement

i

Compound used for displacement:

TAE-684

\(\mathrm{EC}_{50}\):

1 µM

raw data

Comment: NLuc-MOK

Reference: source

Assay window 2.52

\(Z'\) 0.87

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

1111 nM

raw data

Tracer displacement

i

Compound used for displacement:

CTx-0294885

\(\mathrm{EC}_{50}\):

2 µM

raw data

Comment: MST1R-NLuc

Reference: source

Assay window 4.62

\(Z'\) 0.9

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

568 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

17 nM

raw data

Comment: MUSK-NLuc

Reference: source

Assay window 12.47

\(Z'\) 0.92

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

128 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

589 nM

raw data

Comment: MYLK2-NLuc

Reference: source

Assay window 7.57

\(Z'\) 0.95

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

1282 nM

raw data

Tracer displacement

i

Compound used for displacement:

CEP-701

\(\mathrm{EC}_{50}\):

240 nM

raw data

Comment: MYLK3-NLuc

Reference: source

Assay window 4.92

\(Z'\) 0.71

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

218 nM

raw data

Tracer displacement

i

Compound used for displacement:

CEP-701

\(\mathrm{EC}_{50}\):

14 nM

raw data

Comment: MYLK4-NLuc

Reference: source

Assay window 3.44

\(Z'\) 0.91

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

1562 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

344 nM

raw data

Comment: NLuc-NEK1

Reference: source

Assay window 3.43

\(Z'\) 0.7

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

692 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

323 nM

raw data

Comment: NLuc-NEK11

Reference: source

Assay window 2.78

\(Z'\) 0.76

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

748 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

517 nM

raw data

Comment: NLuc-NEK2

Reference: source

Assay window 5.76

\(Z'\) 0.79

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

768 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

561 nM

raw data

Comment: NLuc-NEK3

Reference: source

Assay window 2.25

\(Z'\) 0.81

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

489 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

802 nM

raw data

Comment: NLuc-NEK4

Reference: source

Assay window 6.37

\(Z'\) 0.88

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

84 nM

raw data

Tracer displacement

i

Compound used for displacement:

APY-69

\(\mathrm{EC}_{50}\):

238 nM

raw data

Comment: NLuc-NEK5

Reference: source

Assay window 5.94

\(Z'\) 0.79

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

681 nM

raw data

Tracer displacement

i

Compound used for displacement:

APY-69

\(\mathrm{EC}_{50}\):

569 nM

raw data

Comment: NLuc-NEK9

Reference: source

Assay window 6.19

\(Z'\) 0.92

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

318 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

30 nM

raw data

Comment: NIM1K-NLuc

Reference: source

Assay window 2.47

\(Z'\) 0.79

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

1228 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

351 nM

raw data

Comment: NLK-NLuc

Reference: source

Assay window 4.69

\(Z'\) 0.94

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

359 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

5 nM

raw data

Comment: NTRK1-NLuc

Reference: source

Assay window 4.47

\(Z'\) 0.73

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

445 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

4 nM

raw data

Comment: NTRK2-NLuc

Reference: source

Assay window 3.41

\(Z'\) 0.74

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

29 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

12 nM

raw data

Comment: NLuc-NUAK1

Reference: source

Assay window 2.39

\(Z'\) 0.77

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

193 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

6 nM

raw data

Comment: NUAK2-NLuc

Reference: source

Assay window 7.61

\(Z'\) 0.94

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

585 nM

raw data

Tracer displacement

i

Compound used for displacement:

CEP-701

\(\mathrm{EC}_{50}\):

359 nM

raw data

Comment: PAK4-NLuc

Reference: source

Assay window 3.48

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

377 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

38 nM

raw data

Comment: PAK6-NLuc

Reference: source

Assay window 5.29

\(Z'\) 0.93

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

441 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

1 nM

raw data

Comment: NLuc-PHKG1

Reference: source

Assay window 2.25

\(Z'\) 0.81

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

566 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

6 nM

raw data

Comment: NLuc-PHKG2

Reference: source

Assay window 2.1

\(Z'\) 0.9

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

657 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

3 nM

raw data

Comment: NLuc-PIM3

Reference: source

Assay window 2.48

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

374 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

240 nM

raw data

Comment: NLuc-PLK2

Reference: source

Assay window 2.97

\(Z'\) 0.85

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

257 nM

raw data

Tracer displacement

i

Compound used for displacement:

BI-2536

\(\mathrm{EC}_{50}\):

10 nM

raw data

Comment: NLuc-PLK3

Reference: source

Assay window 4.91

\(Z'\) 0.85

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

370 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

19 nM

raw data

Comment: NLuc-PLK4

Reference: source

Assay window 4.85

\(Z'\) 0.5

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

267 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

2 nM

raw data

Comment: NLuc-PRKAA1

Reference: source

Assay window 5.32

\(Z'\) 0.76

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

106 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

6 nM

raw data

Comment: NLuc-PRKAA2

Reference: source

Assay window 5.4

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

425 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

286 nM

raw data

Comment: PRKACA-NLuc

Reference: source

Assay window 2.19

\(Z'\) 0.82

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

361 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

144 nM

raw data

Comment: PRKACB-NLuc

Reference: source

Assay window 2.61

\(Z'\) 0.58

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

633 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

114 nM

raw data

Comment: PRKCE-NLuc

Reference: source

Assay window 3.11

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

300 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

376 nM

raw data

Comment: PRKX-NLuc

Reference: source

Assay window 3.74

\(Z'\) 0.83

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

130 nM

raw data

Tracer displacement

i

Compound used for displacement:

CTx-0294885

\(\mathrm{EC}_{50}\):

24 nM

raw data

Comment: NLuc-PTK2

Reference: source

Assay window 2.6

\(Z'\) 0.91

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

119 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

239 nM

raw data

Comment: PTK2B-NLuc

Reference: source

Assay window 3.15

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

126 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

177 nM

raw data

Comment: PTK6-NLuc

Reference: source

Assay window 4.27

\(Z'\) 0.71

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

231 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

16 nM

raw data

Comment: RET-NLuc

Reference: source

Assay window 4.45

\(Z'\) 0.85

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

405 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

27 nM

raw data

Comment: RET(M918T)-NLuc

Reference: source

Assay window 4.72

\(Z'\) 0.75

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

203 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

7 nM

raw data

Comment: RET(V804L)-NLuc

Reference: source

Assay window 5.07

\(Z'\) 0.77

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

185 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

5 nM

raw data

Comment: RET(V804M)-NLuc

Reference: source

Assay window 4.74

\(Z'\) 0.87

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

962 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

4 µM

raw data

Comment: NLuc-RIOK2

Reference: source

Assay window 2.24

\(Z'\) 0.86

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

598 nM

raw data

Tracer displacement

i

Compound used for displacement:

APY-69

\(\mathrm{EC}_{50}\):

588 nM

raw data

Comment: NLuc-RIPK1

Reference: source

Assay window 4.73

\(Z'\) 0.73

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

544 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

14 nM

raw data

Comment: NLuc-RIPK2

Reference: source

Assay window 5.53

\(Z'\) 0.83

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

68 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

2 µM

raw data

Comment: NLuc-RPS6KA1

Reference: source

Assay window 3.46

\(Z'\) 0.85

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

125 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

2 µM

raw data

Comment: NLuc-RPS6KA2

Reference: source

Assay window 3.6

\(Z'\) 0.75

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

35 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

517 nM

raw data

Comment: NLuc-RPS6KA3

Assay window 3.46

\(Z'\) 0.82

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

42 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

366 nM

raw data

Comment: NLuc-RPS6KA3(I416V)

Reference: source

Assay window 3.46

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

35 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

889 nM

raw data

Comment: NLuc-RPS6KA3(L608F)

Reference: source

Assay window 4.52

\(Z'\) 0.87

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

69 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

388 nM

raw data

Comment: NLuc-RPS6KA4

Reference: source

Assay window 3.06

\(Z'\) 0.7

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

137 nM

raw data

Tracer displacement

i

Compound used for displacement:

CTx-0294885

\(\mathrm{EC}_{50}\):

43 nM

raw data

Comment: NLuc-RPS6KA6

Reference: source

Assay window 5.85

\(Z'\) 0.95

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

245 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

24 nM

raw data

Comment: NLuc-SBK3

Reference: source

Assay window 3.24

\(Z'\) 0.87

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

471 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

151 nM

raw data

Comment: SGK1-NLuc

Reference: source

Assay window 6.16

\(Z'\) 0.78

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

117 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

1 nM

raw data

Comment: NLuc-SIK1

Reference: source

Assay window 12.95

\(Z'\) 0.78

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

27 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

25 nM

raw data

Comment: NLuc-SNF1LK2

Reference: source

Assay window 6.73

\(Z'\) 0.95

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

518 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

2 nM

raw data

Comment: NLuc-SIK3(59–1321)

Reference: source

Assay window 2.75

\(Z'\) 0.81

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

263 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

3 nM

raw data

Comment: SIK3-NLuc

Assay window 2.4

\(Z'\) 0.61

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

720 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

17 nM

raw data

Comment: NLuc-SLK

Reference: source

Assay window 3.04

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

590 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

205 nM

raw data

Comment: NLuc-SNRK

Reference: source

Assay window 2.47

\(Z'\) 0.92

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

491 nM

raw data

Tracer displacement

i

Compound used for displacement:

Vemurafenib

\(\mathrm{EC}_{50}\):

760 nM

raw data

Comment: NLuc-SRMS

Reference: source

Assay window 3.02

\(Z'\) 0.65

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

448 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

0 nM

raw data

Comment: NLuc-STK10

Reference: source

Assay window 4.26

\(Z'\) 0.91

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

380 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

611 nM

raw data

Comment: NLuc-STK11

Reference: source

Assay window 6.64

\(Z'\) 0.7

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

141 nM

raw data

Tracer displacement

i

Compound used for displacement:

CTx-0294885

\(\mathrm{EC}_{50}\):

50 nM

raw data

Comment: NLuc-STK16

Reference: source

Assay window 2.35

\(Z'\) 0.53

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

738 nM

raw data

Tracer displacement

i

Compound used for displacement:

CEP-701

\(\mathrm{EC}_{50}\):

83 nM

raw data

Comment: STK17B-NLuc

Reference: source

Assay window 2.92

\(Z'\) 0.72

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

275 nM

raw data

Tracer displacement

i

Compound used for displacement:

CEP-701

\(\mathrm{EC}_{50}\):

315 nM

raw data

Comment: NLuc-STK3

Reference: source

Assay window 2.47

\(Z'\) 0.88

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

285 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

187 nM

raw data

Comment: NLuc-STK32B

Reference: source

Assay window 2.79

\(Z'\) 0.73

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

153 nM

raw data

Tracer displacement

i

Compound used for displacement:

CEP-701

\(\mathrm{EC}_{50}\):

405 nM

raw data

Comment: NLuc-STK33

Reference: source

Assay window 3.03

\(Z'\) 0.94

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

570 nM

raw data

Tracer displacement

i

Compound used for displacement:

Bosutinib

\(\mathrm{EC}_{50}\):

26 nM

raw data

Comment: STK35-NLuc

Reference: source

Assay window 4.56

\(Z'\) 0.82

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

572 nM

raw data

Tracer displacement

i

Compound used for displacement:

HG-9-91-01

\(\mathrm{EC}_{50}\):

269 nM

raw data

Comment: NLuc-STK36

Reference: source

Assay window 4.27

\(Z'\) 0.96

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

1328 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

333 nM

raw data

Comment: STK38-NLuc

Reference: source

Assay window 4.12

\(Z'\) 0.83

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

671 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

4 µM

raw data

Comment: STK38L-NLuc

Reference: source

Assay window 3.65

\(Z'\) 0.79

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

126 nM

raw data

Tracer displacement

i

Compound used for displacement:

CEP-701

\(\mathrm{EC}_{50}\):

42 nM

raw data

Comment: NLuc-STK4

Reference: source

Assay window 5.12

\(Z'\) 0.81

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

153 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

27 nM

raw data

Comment: NLuc-TBK1

Reference: source

Assay window 4.32

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

403 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

308 nM

raw data

Comment: NLuc-TEC

Reference: source

Assay window 5.74

\(Z'\) 0.72

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

502 nM

raw data

Tracer displacement

i

Compound used for displacement:

CTx-0294885

\(\mathrm{EC}_{50}\):

24 nM

raw data

Comment: TEK-NLuc

Reference: source

Assay window 15.33

\(Z'\) 0.86

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

438 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

66 nM

raw data

Comment: TEK(A1124V)-NLuc

Reference: source

Assay window 18.35

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

278 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

114 nM

raw data

Comment: TEK(P883A)-NLuc

Reference: source

Assay window 23.14

\(Z'\) 0.88

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

330 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

71 nM

raw data

Comment: TEK(R849W)-NLuc

Reference: source

Assay window 18.14

\(Z'\) 0.95

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

244 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

105 nM

raw data

Comment: TEK(Y1108F)-NLuc

Reference: source

Assay window 15.6

\(Z'\) 0.84

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

355 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

111 nM

raw data

Comment: TEK(Y897C)-NLuc

Reference: source

Assay window 14.59

\(Z'\) 0.98

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

352 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

192 nM

raw data

Comment: TEK(Y897S)-NLuc

Reference: source

Assay window 5.18

\(Z'\) 0.71

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

436 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

281 nM

raw data

Comment: TIE1-NLuc

Reference: source

Assay window 2.77

\(Z'\) 0.94

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

252 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

540 nM

raw data

Comment: TLK1-NLuc

Reference: source

Assay window 3.3

\(Z'\) 0.94

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

259 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

614 nM

raw data

Comment: TLK2-NLuc

Reference: source

Assay window 5.01

\(Z'\) 0.76

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

36 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

30 nM

raw data

Comment: NLuc-TNK1

Reference: source

Assay window 6.04

\(Z'\) 0.82

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

149 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

136 nM

raw data

Comment: TNK2-NLuc

Reference: source

Assay window 3.2

\(Z'\) 0.92

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

404 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

16 nM

raw data

Comment: TNNI3K-NLuc

Reference: source

Assay window 2.46

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

660 nM

raw data

Tracer displacement

i

Compound used for displacement:

Dasatinib

\(\mathrm{EC}_{50}\):

7 nM

raw data

Comment: TXK-NLuc

Reference: source

Assay window 2.92

\(Z'\) 0.94

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

934 nM

raw data

Tracer displacement

i

Compound used for displacement:

Pacritinib

\(\mathrm{EC}_{50}\):

2 µM

raw data

Comment: TYK2-NLuc

Reference: source

Assay window 2.14

\(Z'\) 0.88

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

3501 nM

raw data

Tracer displacement

i

Compound used for displacement:

Cerdulatinib

\(\mathrm{EC}_{50}\):

113 nM

raw data

Comment: TYK2(897–1187)-NLuc

Reference: source

Assay window 4.63

\(Z'\) 0.94

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

1587 nM

raw data

Tracer displacement

i

Compound used for displacement:

Cerdulatinib

\(\mathrm{EC}_{50}\):

26 nM

raw data

Comment: TYK2(589–875)-NLuc

Reference: source

Assay window 2.22

\(Z'\) 0.9

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

340 nM

raw data

Tracer displacement

i

Compound used for displacement:

Foretinib

\(\mathrm{EC}_{50}\):

11 nM

raw data

Comment: TYRO3-NLuc

Reference: source

Assay window 10.4

\(Z'\) 0.8

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

237 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

114 nM

raw data

Comment: NLuc-ULK1

Reference: source

Assay window 4.69

\(Z'\) 0.83

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

951 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

28 nM

raw data

Comment: NLuc-ULK2

Reference: source

Assay window 16.67

\(Z'\) 0.78

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

358 nM

raw data

Tracer displacement

i

Compound used for displacement:

Staurosporine

\(\mathrm{EC}_{50}\):

226 nM

raw data

Comment: NLuc-ULK3

Reference: source

Assay window 3.53

\(Z'\) 0.76

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

178 nM

raw data

Tracer displacement

i

Compound used for displacement:

CTx-0294885

\(\mathrm{EC}_{50}\):

12 nM

raw data

Comment: WEE1-NLuc

Reference: source

Assay window 2.46

\(Z'\) 0.89

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

272 nM

raw data

Tracer displacement

i

Compound used for displacement:

CC1

\(\mathrm{EC}_{50}\):

78 nM

raw data

Comment: NLuc-WEE2

Reference: source