|T000064, CDK19 Tracer (NB535)
Compound Image

T000064

CDK19 Tracer (NB535)

  • Description

    Formula:

    C37H32BF2N5O3S

    avg. MolWt:

    675.57 u

    PAINS elements:

    none detected

    SMILES:

    display
  • Properties

    Store at:

    -80 °C

    Absorption:

    450 nm

    Emission:

    590 nm

    clogP:

    7.05
  • References

    Contributing Lab:

    Knapp Lab, University of Frankfurt

  • Experimental

    Assay window 2.2
    \(Z'\) 0.59
    CP agreement yes
    Tracer titration

    \(K_\mathrm{D}^{\,\mathrm{app}}\):

    4019 nM
    titration curve
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    OTS964

    \(\mathrm{EC}_{50}\):

    30 nM
    displacement curve
    raw data

    Comment: NLuc-CDK19 + CycL2

    Assay window 1.52
    \(Z'\) 0.54
    CP agreement yes
    Tracer titration

    \(K_\mathrm{D}^{\,\mathrm{app}}\):

    95 nM
    titration curve
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    Dinaciclib

    \(\mathrm{EC}_{50}\):

    84 nM
    displacement curve
    raw data

    Comment: NLuc-CDK9 without Cyclin activation