|T000063, TAOK Tracer
Compound Image

T000063

TAOK Tracer

  • Description

    Formula:

    C52H59BF5N11O4

    avg. MolWt:

    1007.92 u

    PAINS elements:

    none detected

    SMILES:

    display
  • Properties

    Store at:

    -80 °C

    Absorption:

    450 nm

    Emission:

    590 nm

    clogP:

    8.09
  • References

    Contributing Lab:

    Knapp Lab, University of Frankfurt

  • Experimental

    : 3.3

    Z’: 0.95

    : yes

    Tracer titration

    KD:

    1136 nM
    ...
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    Staurosporine

    IC50:

    645 nM
    raw data

    Comment: NLuc-TAOK2

    : 4.1

    Z’: 0.97

    : yes

    Tracer titration

    KD:

    1777 nM
    ...
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    Staurosporine

    IC50:

    67 nM
    raw data

    Comment: NLuc-TAOK3

    : 3.6

    Z’: 0.9

    : yes

    Tracer titration

    KDapp:

    > 10 µM
    ...
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    Staurosporine

    EC50:

    809 nM
    raw data

    Comment: NLuc-TAOK3; Although the parameters allow a classification as robust assay, the classification was changed to expert because fluctuations in quality were observed