|T000054, Clozapine Tracer G-4 (CS315422)
Compound Image

T000054

Clozapine Tracer G-4 (CS315422)

  • Description

    Formula:

    C47H57BClF2N9O6

    avg. MolWt:

    928.29 u

    PAINS elements:

    none detected

    SMILES:

    display
  • Properties

    Store at:

    -80 °C

    Absorption:

    450 nm

    Emission:

    590 nm

    clogP:

    5.58
  • References

    Contributing Lab:

    Promega Corp., Madison

    Vendor:

    Promega
  • Experimental

    Assay window 2.3
    \(Z'\) 0.58
    CP agreement yes
    Tracer titration

    \(K_\mathrm{D}^{\,\mathrm{app}}\):

    101 nM
    titration curve
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    Serotonin

    \(\mathrm{EC}_{50}\):

    66 nM
    displacement curve
    raw data

    Comment: IL6-HiBiT-HTR1B

    Reference: PMID

    Assay window 1.7
    \(Z'\) 0.6
    CP agreement yes
    Tracer titration

    \(K_\mathrm{D}^{\,\mathrm{app}}\):

    369 nM
    titration curve
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    Clozapine

    \(\mathrm{EC}_{50}\):

    713 nM
    displacement curve
    raw data

    Comment: IL6-HiBiT-HTR2C(33-458)

    Reference: PMID