|T000050, KDM5 Tracer

Compound Image

T000050

KDM5 Tracer

Description

Formula:

C₃₇H₄₀BF₂N₁₁O₃

avg. MolWt:

735.61 u

PAINS elements:

none detected

SMILES:

display

Properties

Store at:

-80 °C

Absorption:

450 nm

Emission:

590 nm

clogP:

4.09
References

Contributing Lab:

Promega Corp., Madison
Experimental

: 4.99

Z’: 0.73

: yes

Tracer titration

KD_app:

> 10 µM

raw data

Tracer displacement

i

Compound used for displacement:

unlabelled parent ligand

EC₅₀:

713 nM

raw data

Comment: NLuc-KDM5A

: 4.73

Z’: 0.76

: yes

Tracer titration

KD_app:

6510 nM

raw data

Tracer displacement

i

Compound used for displacement:

unlabelled parent ligand

EC₅₀:

539 nM

raw data

Comment: NLuc-KDM5B

: 5.89

Z’: 0.62

: yes

Tracer titration

K_D:

1917 nM

raw data

Tracer displacement

i

Compound used for displacement:

GSK467

IC₅₀:

72 µM

raw data

Comment: NLuc-KDM5B

: 4.47

Z’: 0.69

: yes

Tracer titration

KD_app:

> 10 µM

raw data

Tracer displacement

i

Compound used for displacement:

unlabelled parent ligand

EC₅₀:

1 µM

raw data

Comment: NLuc-KDM5C

: 9.03

Z’: 0.71

: yes

Tracer titration

K_D:

1391 nM

raw data

Tracer displacement

i

Compound used for displacement:

GSK467

IC₅₀:

20 nM

raw data

Comment: NLuc-KDM5C