|T000050, KDM5 Tracer

Compound Image

T000050

KDM5 Tracer

Description

Formula:

C₃₇H₄₀BF₂N₁₁O₃

avg. MolWt:

735.61 u

PAINS elements:

none detected

SMILES:

display

Properties

Store at:

-80 °C

Absorption:

450 nm

Emission:

590 nm

clogP:

4.09
References

Contributing Lab:

Promega Corp., Madison
Experimental

Assay window 4.99

\(Z'\) 0.73

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

> 10 µM

raw data

Tracer displacement

i

Compound used for displacement:

unlabelled parent ligand

\(\mathrm{EC}_{50}\):

713 nM

raw data

Comment: NLuc-KDM5A

Assay window 4.73

\(Z'\) 0.76

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

6510 nM

raw data

Tracer displacement

i

Compound used for displacement:

unlabelled parent ligand

\(\mathrm{EC}_{50}\):

539 nM

raw data

Comment: NLuc-KDM5B

Assay window 5.89

\(Z'\) 0.62

CP agreement yes

Tracer titration

\(K_\mathrm{D}\):

1917 nM

raw data

Tracer displacement

i

Compound used for displacement:

GSK467

\(\mathrm{IC}_{50}\):

72 µM

raw data

Comment: NLuc-KDM5B

Assay window 4.47

\(Z'\) 0.69

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

> 10 µM

raw data

Tracer displacement

i

Compound used for displacement:

unlabelled parent ligand

\(\mathrm{EC}_{50}\):

1 µM

raw data

Comment: NLuc-KDM5C

Assay window 9.03

\(Z'\) 0.71

CP agreement yes

Tracer titration

\(K_\mathrm{D}\):

1391 nM

raw data

Tracer displacement

i

Compound used for displacement:

GSK467

\(\mathrm{IC}_{50}\):

20 nM

raw data

Comment: NLuc-KDM5C