|T000042, HDAC Tracer
Compound Image

T000042

HDAC Tracer

  • Description

    Formula:

    C50H56N5O7+

    avg. MolWt:

    839.03 u

    PAINS elements:

    detected (1)

    SMILES:

    display
  • Properties

    Store at:

    -20 °C

    Absorption:

    450 nm

    Emission:

    618 nm

    clogP:

    6.31
  • References

    Contributing Lab:

    Promega Corp., Madison

    Vendor:

    Promega
  • Experimental

    Assay window 2.85
    \(Z'\) 0.65
    CP agreement yes
    Tracer titration

    \(K_\mathrm{D}^{\,\mathrm{app}}\):

    5 nM
    titration curve
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    CI-994

    \(\mathrm{EC}_{50}\):

    8 µM
    displacement curve
    raw data

    Comment: HDAC1-NLuc

    Reference: PMID

    Assay window 1.52
    \(Z'\) 0.74
    CP agreement yes
    Tracer titration

    \(K_\mathrm{D}^{\,\mathrm{app}}\):

    39 nM
    titration curve
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    CI-994

    \(\mathrm{EC}_{50}\):

    2 µM
    displacement curve
    raw data

    Comment: HDAC3-NLuc

    Reference: PMID