|T000040, K3 Tracer

Compound Image

T000040

K3 Tracer

Properties

Store at:

-80 °C

Absorption:

450 nm

Emission:

590 nm
References

Contributing Lab:

Promega Corp., Madison

Vendor:

Promega
Experimental

: 5.75

Z’: 0.82

: yes

Tracer titration

KD_app:

27 nM

raw data

Tracer displacement

i

Compound used for displacement:

Alpelisib

EC₅₀:

21 nM

raw data

Comment: NLuc-PIK3CA + PIK3R1

Reference: source

: 3.11

Z’: 0.65

: yes

Tracer titration

KD_app:

16 nM

raw data

Tracer displacement

i

Compound used for displacement:

PI-103

EC₅₀:

87 nM

raw data

Comment: NLuc-PIK3CA(C420R) + PIK3R1

Reference: source

: 2.92

Z’: 0.54

: yes

Tracer titration

KD_app:

24 nM

raw data

Tracer displacement

i

Compound used for displacement:

PI-103

EC₅₀:

76 nM

raw data

Comment: NLuc-PIK3CA(E542K) + PIK3R1

Reference: source

: 3.2

Z’: 0.65

: yes

Tracer titration

KD_app:

18 nM

raw data

Tracer displacement

i

Compound used for displacement:

PI-103

EC₅₀:

69 nM

raw data

Comment: NLuc-PIK3CA(E545A) + PIK3R1

Reference: source

: 4.04

Z’: 0.63

: yes

Tracer titration

KD_app:

22 nM

raw data

Tracer displacement

i

Compound used for displacement:

PI-103

EC₅₀:

63 nM

raw data

Comment: NLuc-PIK3CA(E545K) + PIK3R1

Reference: source

: 4.39

Z’: 0.82

: yes

Tracer titration

KD_app:

38 nM

raw data

Tracer displacement

i

Compound used for displacement:

PI-103

EC₅₀:

57 nM

raw data

Comment: NLuc-PIK3CA(H1047L) + PIK3R1

Reference: source

: 4.04

Z’: 0.54

: yes

Tracer titration

KD_app:

27 nM

raw data

Tracer displacement

i

Compound used for displacement:

PI-103

EC₅₀:

67 nM

raw data

Comment: NLuc-PIK3CA(H1047R) + PIK3R1

Reference: source

: 5.14

Z’: 0.78

: yes

Tracer titration

KD_app:

33 nM

raw data

Tracer displacement

i

Compound used for displacement:

PI-103

EC₅₀:

59 nM

raw data

Comment: NLuc-PIK3CA(H1047Y) + PIK3R1

Reference: source

: 4.15

Z’: 0.71

: yes

Tracer titration

KD_app:

51 nM

raw data

Tracer displacement

i

Compound used for displacement:

PI-103

EC₅₀:

47 nM

raw data

Comment: NLuc-PIK3CA(I800L) + PIK3R1

Reference: source

: 3.5

Z’: 0.74

: yes

Tracer titration

KD_app:

30 nM

raw data

Tracer displacement

i

Compound used for displacement:

PI-103

EC₅₀:

44 nM

raw data

Comment: NLuc-PIK3CA(Q546K) + PIK3R1

Reference: source

: 4.35

Z’: 0.76

: yes

Tracer titration

KD_app:

184 nM

raw data

Tracer displacement

i

Compound used for displacement:

PI-103

EC₅₀:

35 nM

raw data

Comment: NLuc-PIK3CB + PIK3R1

Reference: source

: 3.4

Z’: 0.85

: yes

Tracer titration

KD_app:

77 nM

raw data

Tracer displacement

i

Compound used for displacement:

Apitolisib

EC₅₀:

65 nM

raw data

Comment: NLuc-PIK3CD + PIK3R1

Reference: source