|T000036, Palbociclib-FITC
Compound Image

T000036

Palbociclib-FITC

  • Description

    Formula:

    C51H53N9O7S

    avg. MolWt:

    936.11 u

    PAINS elements:

    none detected

    SMILES:

    display
  • Properties

    Store at:

    -20 °C

    Absorption:

    475 nm

    Emission:

    520 nm

    clogP:

    8.51
  • References

    Synthesis:

    Publication

    Contributing Lab:

    Mazitschek Lab, Massachusetts General Hospital, Boston and Woo Lab, Harvard University, Boston

  • Experimental

    Assay window 33.6
    \(Z'\) 0.91
    CP agreement yes
    Tracer titration

    \(K_\mathrm{D}\):

    6 nM
    titration curve
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    dCDK-1

    \(\mathrm{IC}_{50}\):

    54 nM
    displacement curve
    raw data

    Comment: 1 nM CoraFluor-1-labeled anti-His6 antibody; 2 nM His6-GST-CDK4/GST-CD3

    Reference: PMID

    Assay window 23.4
    \(Z'\) 0.87
    CP agreement yes
    Tracer titration

    \(K_\mathrm{D}\):

    263 nM
    titration curve
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    dCDK-1

    \(\mathrm{IC}_{50}\):

    338 nM
    displacement curve
    raw data

    Comment: 1 nM CoraFluor-1-labeled anti-His6 antibody; 2 nM His6-CDK6/GST-CD1

    Reference: PMID