|T000016, EGFR Tracer
Compound Image

T000016

EGFR Tracer

  • Description

    Formula:

    C41H42BClF3N9O4

    avg. MolWt:

    828.11 u

    PAINS elements:

    none detected

    SMILES:

    display
  • Properties

    Store at:

    -80 °C

    Absorption:

    450 nm

    Emission:

    590 nm

    clogP:

    6.52
  • References

    Synthesis:

    Publication

    Contributing Lab:

    Knapp Lab, University of Frankfurt

  • Experimental

    Assay window 2.5
    \(Z'\) 0.79
    CP agreement yes
    Tracer titration

    \(K_\mathrm{D}^{\,\mathrm{app}}\):

    664 nM
    titration curve
    raw data
    Tracer displacement
    i

    Compound used for displacement:

    Erlotinib

    \(\mathrm{EC}_{50}\):

    300 nM
    displacement curve
    raw data

    Comment: EGFR-NLuc construct

    Reference: PMID