|T000010, SRPK Tracer

T000010

SRPK Tracer

Description

Formula:

C₄₆H₅₂BF₂N₁₁O₇S

avg. MolWt:

951.87 u

PAINS elements:

none detected

SMILES:

display

Properties

Store at:

-80 °C

Absorption:

450 nm

Emission:

590 nm

clogP:

4.61
References

Synthesis:

Publication

Contributing Lab:

Knapp Lab, University of Frankfurt
Experimental

Assay window 2.7

\(Z'\) 0.6

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

4285 nM

raw data

Tracer displacement

i

Compound used for displacement:

MSC-1186

\(\mathrm{EC}_{50}\):

81 nM

raw data

Comment: SRPK1-NLuc

Reference: PMID

Assay window 4.0

\(Z'\) 0.6

CP agreement yes

Tracer titration

\(K_\mathrm{D}\):

5054 nM

raw data

Tracer displacement

i

Compound used for displacement:

MSC-1186

\(\mathrm{IC}_{50}\):

90 nM

raw data

Comment: SRPK1-NLuc

Reference: PMID

Assay window 1.7

\(Z'\) 0.6

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

1975 nM

raw data

Tracer displacement

i

Compound used for displacement:

MSC-1186

\(\mathrm{EC}_{50}\):

25 nM

raw data

Comment: NLuc-SRPK2

Reference: PMID

Assay window 1.8

\(Z'\) 0.5

CP agreement yes

Tracer titration

\(K_\mathrm{D}\):

1680 nM

raw data

Tracer displacement

i

Compound used for displacement:

MSC-1186

\(\mathrm{IC}_{50}\):

866 nM

raw data

Comment: NLuc-SRPK2

Reference: PMID

Assay window 2.6

\(Z'\) 0.5

CP agreement yes

Tracer titration

\(K_\mathrm{D}^{\,\mathrm{app}}\):

5815 nM

raw data

Tracer displacement

i

Compound used for displacement:

MSC-1186

\(\mathrm{EC}_{50}\):

29 nM

raw data

Comment: NLuc-SRPK3

Reference: PMID

Assay window 4.2

\(Z'\) 0.6

CP agreement yes

Tracer titration

\(K_\mathrm{D}\):

694 nM

raw data

Tracer displacement

i

Compound used for displacement:

MSC-1186

\(\mathrm{IC}_{50}\):

31 nM

raw data

Comment: NLuc-SRPK3

Reference: PMID